Entity Central Index Key Lessee, operating lease liability payments due after year four. Cover [Abstract] Document Type Document Type Amendment Flag Amendment Flag Document Period End Date Document Period End Date Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Trading Symbol Trading Symbol Entity Registrant Name Entity Registrant Name Entity Central Index Key Entity Central Index Key Entity Current Reporting Status Entity Current Reporting Status Current Fiscal Year End Date Current Fiscal Year End Date Entity Filer Category Entity Filer Category Entity Shell Company Entity Shell Company Entity Small Business Entity Small Business Entity Emerging Growth Company Entity Emerging Growth Company Entity Ex Transition Period Entity Ex Transition Period Entity Common Stock, Shares Outstanding Entity Common Stock Shares Outstanding Entity File Number Entity File Number Entity Tax Identification Number Entity Tax Identification Number Entity Address, Address Line One Entity Address Address Line1 Entity Address, City or Town Entity Address City Or Town Entity Address, State or Province Entity Address State Or Province Entity Address, Postal Zip Code Entity Address Postal Zip Code City Area Code City Area Code Local Phone Number Local Phone Number Entity Interactive Data Current Entity Interactive Data Current Title of 12(b) Security Security12b Title Security Exchange Name Security Exchange Name Entity Incorporation, State or Country Code Entity Incorporation State Country Code Document Quarterly Report Document Quarterly Report Document Transition Report Document Transition Report Liability related to sale of future royalties. Statement Of Financial Position [Abstract] Assets Assets [Abstract] Current assets: Assets Current [Abstract] Cash and cash equivalents Cash And Cash Equivalents At Carrying Value Marketable securities Marketable Securities Current Prepaid expenses and other current assets Prepaid Expense And Other Assets Current Total current assets Assets Current Marketable securities Marketable Securities Noncurrent Restricted cash Restricted Cash Noncurrent Property and equipment, net Property Plant And Equipment Net Operating lease right-of-use asset Operating Lease Right Of Use Asset Other assets Other Assets Noncurrent Total assets Assets Liabilities and stockholders’ equity Liabilities And Stockholders Equity [Abstract] Current liabilities: Liabilities Current [Abstract] Accounts payable Accounts Payable Current Accrued and other current liabilities Accrued Liabilities Current Operating lease liability Operating Lease Liability Current Total current liabilities Liabilities Current Operating lease liability, net of current portion Operating Lease Liability Noncurrent Liability related to sale of future royalties Liability Related To Sale Of Future Royalties Other liabilities Other Liabilities Noncurrent Total liabilities Liabilities Commitments and contingencies (Note 6) Commitments And Contingencies Stockholders’ equity: Stockholders Equity [Abstract] Preferred stock, $0.0001 par value, 10,000,000 shares authorized; 0 shares issued and outstanding at September 30, 2020 and December 31, 2019 Preferred Stock Value Common stock, $0.0001 par value, 490,000,000 shares authorized at September 30, 2020 and December 31, 2019; 44,760,513 and 44,413,404 shares issued and outstanding at September 30, 2020 and December 31, 2019, respectively Common Stock Value Additional paid-in capital Additional Paid In Capital Common Stock Accumulated other comprehensive income Accumulated Other Comprehensive Income Loss Net Of Tax Accumulated deficit Retained Earnings Accumulated Deficit Total stockholders’ equity Stockholders Equity Total liabilities and stockholders’ equity Liabilities And Stockholders Equity Preferred stock, par value Preferred Stock Par Or Stated Value Per Share Preferred stock, shares authorized Preferred Stock Shares Authorized Preferred Stock, shares issued Preferred Stock Shares Issued Preferred Stock, shares outstanding Preferred Stock Shares Outstanding Common stock, par value Common Stock Par Or Stated Value Per Share Common stock, shares authorized Common Stock Shares Authorized Common stock, shares issued Common Stock Shares Issued Common stock, shares outstanding Common Stock Shares Outstanding Income Statement [Abstract] Operating expenses Operating Expenses [Abstract] Research and development Research And Development Expense General and administrative General And Administrative Expense Total operating expenses Operating Expenses Loss from operations Operating Income Loss Interest income Investment Income Interest Interest expense Interest Expense Other income (expense), net Other Nonoperating Income Expense Net loss Net Income Loss Net loss per common share, basic and diluted Earnings Per Share Basic And Diluted Weighted-average common shares outstanding used in computing net loss per common share, basic and diluted Weighted Average Number Of Share Outstanding Basic And Diluted Other comprehensive income (loss) Other Comprehensive Income Loss Net Of Tax Portion Attributable To Parent [Abstract] Change in unrealized gains related to available-for-sale debt securities, net of tax Other Comprehensive Income Availableforsale Securities Adjustment Net Of Tax Portion Attributable To Parent Total other comprehensive income (loss) Other Comprehensive Income Loss Net Of Tax Portion Attributable To Parent Comprehensive loss Comprehensive Income Net Of Tax Issuance of common stock upon vesting of restricted stock units,net of taxes withheld, shares. Issuance of common stock upon vesting of restricted stock units,net of taxes withheld. Issuance of common stock upon exercise of common stock warrants, shares. Issuance of common stock upon exercise of common stock warrants. Statement Of Stockholders Equity [Abstract] Statement [Table] Statement [Table] Equity Components Statement Equity Components [Axis] Equity Component Equity Component [Domain] Common Stock Common Stock [Member] Additional Paid-In Capital Additional Paid In Capital [Member] Accumulated Other Comprehensive Income (Loss) Accumulated Other Comprehensive Income [Member] Accumulated Deficit Retained Earnings [Member] Statement [Line Items] Statement [Line Items] Beginning Balance Beginning balance, shares Shares Outstanding Issuance of common stock upon exercise of stock options Stock Issued During Period Value Stock Options Exercised Issuance of common stock upon exercise of stock options, shares Stock Issued During Period Shares Stock Options Exercised Issuance of common stock upon vesting of restricted stock units, net of taxes withheld Issuance Of Common Stock Upon Vesting Of Restricted Stock Units Net Of Taxes Withheld Issuance of common stock upon vesting of restricted stock units, net of taxes withheld, shares Issuance Of Common Stock Upon Vesting Of Restricted Stock Units Net Of Taxes Withheld Shares Issuance of common stock upon exercise of common stock warrant Issuance Of Common Stock Upon Exercise Of Common Stock Warrants Issuance of common stock upon exercise of common stock warrant, shares Issuance Of Common Stock Upon Exercise Of Common Stock Warrants Shares Stock-based compensation expense Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value Other comprehensive income (loss) Net loss Ending Balance Ending balance, shares Operating lease right of use asset amortization. Increase decrease in operating lease liability. Proceeds from sale of future royalties, net of issuance costs. Principal payments of tenant improvement allowance payable. Statement Of Cash Flows [Abstract] Cash flows from operating activities Net Cash Provided By Used In Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract] Depreciation Depreciation Stock-based compensation Share Based Compensation Amortization (accretion) of premium (discount) on marketable securities Accretion Amortization Of Discounts And Premiums Investments Amortization of operating lease right-of-use asset Operating Lease Right Of Use Asset Amortization Amortization of issuance costs Amortization Of Financing Costs Changes in assets and liabilities: Increase Decrease In Operating Capital [Abstract] Prepaid expenses and other current assets Increase Decrease In Prepaid Deferred Expense And Other Assets Other assets Increase Decrease In Other Operating Assets Accounts payable Increase Decrease In Accounts Payable Accrued and other current liabilities Increase Decrease In Accrued Liabilities And Other Operating Liabilities Operating lease liability Increase Decrease In Operating Lease Liability Net cash used in operating activities Net Cash Provided By Used In Operating Activities Cash flows from investing activities Net Cash Provided By Used In Investing Activities [Abstract] Purchase of property and equipment Payments To Acquire Property Plant And Equipment Purchase of marketable securities Payments To Acquire Marketable Securities Maturities of marketable securities Proceeds From Sale And Maturity Of Marketable Securities Net cash provided by (used in) investing activities Net Cash Provided By Used In Investing Activities Cash flows from financing activities Net Cash Provided By Used In Financing Activities [Abstract] Proceeds from issuance of common stock upon options exercise Proceeds From Stock Options Exercised Payments for restricted stock units, net of taxes withheld Payments Related To Tax Withholding For Share Based Compensation Proceeds from sale of future royalties, net of issuance costs Proceeds From Sale Of Future Royalties Net Of Issuance Costs Principal payments of capital lease Repayments Of Debt And Capital Lease Obligations Principal payments of tenant improvement allowance payable Principal Payments Of Tenant Improvement Allowance Payable Net cash provided by financing activities Net Cash Provided By Used In Financing Activities Net increase (decrease) in cash, cash equivalents and restricted cash Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Excluding Exchange Rate Effect Cash, cash equivalents and restricted cash, at beginning of period Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations Cash, cash equivalents and restricted cash, at end of period Reconciliation of cash, cash equivalents and restricted cash to consolidated balance sheets Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents [Abstract] Supplemental disclosures of non-cash investing and financing information: Cash Flow Noncash Investing And Financing Activities Disclosure [Abstract] Operating lease right-of-use asset obtained in exchange for operating lease liability Right Of Use Asset Obtained In Exchange For Operating Lease Liability Purchase of property and equipment under accounts payable Noncash Or Part Noncash Acquisition Fixed Assets Acquired1 The entire disclosure for the company. Organization Consolidation And Presentation Of Financial Statements [Abstract] The Company The Company [Text Block] Accounting Policies [Abstract] Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] Accounts Payable And Accrued Liabilities Current [Abstract] Accrued and Other Current Liabilities Accounts Payable Accrued Liabilities And Other Liabilities Disclosure Current [Text Block] Fair Value Disclosures [Abstract] Fair Value Measurements Fair Value Disclosures [Text Block] Investments Debt And Equity Securities [Abstract] Marketable Securities Investments In Debt And Marketable Equity Securities And Certain Trading Assets Disclosure [Text Block] Commitments And Contingencies Disclosure [Abstract] Commitments and Contingencies Commitments And Contingencies Disclosure [Text Block] Liability related to sale of future royalties. Liability related to sale of future royalties. Liability Related To Sale Of Future Royalties [Abstract] Liability related to Sale of Future Royalties Liability Related To Sale Of Future Royalties [Text Block] Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] Stock-Based Compensation Disclosure Of Compensation Related Costs Share Based Payments [Text Block] Earnings Per Share [Abstract] Net Loss per Common Share Earnings Per Share [Text Block] Basis of Presentation and Principles of Consolidation Basis Of Accounting Policy Policy [Text Block] Reclassification Prior Period Reclassification Adjustment Description Use of Estimates Use Of Estimates Disclosure of accounting policy for risks and uncertainties. Risks and Uncertainties Risks And Uncertainties Policy [Text Block] Liability related to sale of future royalties. Liability related to Sale of Future Royalties Liability Related To Sale Of Future Royalties Policy [Text Block] Credit Losses – Available-for-Sale Debt Securities Credit Loss Financial Instrument Policy [Text Block] Recent Accounting Pronouncements New Accounting Pronouncements Policy Policy [Text Block] Schedule of accrued and other current liabilities. Schedule of Accrued and Other Current Liabilities Schedule Of Accrued And Other Current Liabilities Table [Text Block] Summary of Fair Value Hierarchy for Assets Measured at Fair Value on Recurring Basis Fair Value Assets Measured On Recurring Basis [Text Block] Summary of Marketable Securities Held Marketable Securities [Text Block] Summary of Maturities of Operating Lease Liabilities Lessee Operating Lease Liability Maturity Table [Text Block] Summary of Stock Options Activity under 2018 Plan and 2015 Equity Incentive Plan Schedule Of Share Based Compensation Stock Options Activity Table [Text Block] Summary of Restricted Shares Schedule Of Sharebased Compensation Restricted Stock And Restricted Stock Units Activity Table [Text Block] Summary of Stock-based Compensation for Options and Restricted Shares Classified in Condensed Consolidated Statements of Operations and Comprehensive Loss Schedule Of Compensation Cost For Share Based Payment Arrangements Allocation Of Share Based Compensation Costs By Plan Table [Text Block] Summary of Anti-dilutive Securities Excluded from Computation of Diluted Net Loss per Common Share Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block] Cash and cash equivalents and marketable securities Cash Cash Equivalents And Short Term Investments Capped percentage of royalty on future net sales. Related party transaction ownership percentage threshold. Summary of significant accounting policies. Summary of significant accounting policies. Summary Of Significant Accounting Policies [Table] Summary Of Significant Accounting Policies [Table] Related Party Transaction Related Party Transaction [Axis] Related Party Transaction Related Party Transaction [Domain] Baker bros advisors LP. Baker Bros. Advisors LP Baker Bros Advisors L P [Member] Statistical Measurement Range [Axis] Statistical Measurement Range [Member] Minimum Minimum [Member] Maximum [Member] Maximum [Member] Collaborative Arrangement and Arrangement Other than Collaborative Type Of Arrangement [Axis] Collaborative Arrangement and Arrangement Other than Collaborative Arrangements And Nonarrangement Transactions [Member] Funding agreement. Funding Agreement Funding Agreement [Member] Accounting Standards Update Adjustments For New Accounting Pronouncements [Axis] Accounting Standards Update Type Of Adoption [Member] ASU 2016-13 Accounting Standards Update201613 [Member] Summary of Significant Accounting Policies [Line Items] Summary Of Significant Accounting Policies [Line Items] Capped percentage of royalty on future net sales Capped Percentage Of Royalty On Future Net Sales Amount under funding agreement Debt Instrument Face Amount Ownership percentage threshold Related Party Transaction Ownership Percentage Threshold Allowance for credit losses for available-for-sale debt securities Debt Securities Available For Sale Allowance For Credit Loss Accrued research and development current. Accrued legal fees current. Accrued research and development Accrued Research And Development Current Accrued salaries and benefits Employee Related Liabilities Current Accrued professional fees Accrued Professional Fees Current Accrued legal fees Accrued Legal Fees Current Accrued other liabilities Other Accrued Liabilities Current Total accrued and other current liabilities Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table] Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table] Significant Observable Inputs (Level 2) Fair Value By Fair Value Hierarchy Level [Axis] Fair Value Hierarchy and NAV Fair Value Measurements Fair Value Hierarchy [Domain] Quoted Price in Active Markets (Level 1) Fair Value Inputs Level1 [Member] Significant Observable Inputs (Level 2) Fair Value Inputs Level2 [Member] Significant Unobservable Inputs (Level 3) Fair Value Inputs Level3 [Member] Measurement Frequency Fair Value By Measurement Frequency [Axis] Measurement Frequency Fair Value Measurement Frequency [Domain] Fair Value, Measurements, Recurring Fair Value Measurements Recurring [Member] Asset Class Fair Value By Asset Class [Axis] Asset Class Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation By Asset Class [Domain] Money Market Funds Money Market Funds [Member] U.S. Treasury Securities U S Treasury Securities [Member] Commercial Paper Commercial Paper [Member] Corporate Notes Corporate Note Securities [Member] Repurchase agreement. Repurchase Agreements Repurchase Agreement [Member] Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] Cash equivalents Cash And Cash Equivalents Fair Value Disclosure Marketable securities Available For Sale Securities Debt Securities Total Assets Fair Value Disclosure Available for sale debt securities amortized cost basis current. Available for sale debt securities accumulated gross unrealized gain before tax, current. Available for sale debt securities accumulated gross unrealized loss before tax current. Available for sale securities amortized cost basis noncurrent. Available for sale debt securities accumulated gross unrealized gain before tax non current. Available for sale debt securities accumulated gross unrealized loss before tax non current. Marketable Securities [Table] Marketable Securities [Table] Investment Type Investment Type [Axis] Investments Investment Type Categorization [Member] Marketable Securities [Line Items] Marketable Securities [Line Items] Amortized Cost, current Available For Sale Debt Securities Amortized Cost Basis Current Unrealized Gains, current Available For Sale Debt Securities Accumulated Gross Unrealized Gain Before Tax Current Unrealized Losses, current Available For Sale Debt Securities Accumulated Gross Unrealized Loss Before Tax Current Fair Value, current Available For Sale Securities Debt Securities Current Amortized Cost, noncurrent Available For Sale Debt Securities Amortized Cost Basis Noncurrent Unrealized Gains, noncurrent Available For Sale Debt Securities Accumulated Gross Unrealized Gain Before Tax Non Current Unrealized Losses, noncurrent Available For Sale Debt Securities Accumulated Gross Unrealized Loss Before Tax Non Current Fair Value, noncurrent Available For Sale Securities Debt Securities Noncurrent Maximum Marketable securities, contractual maturities Debt Securities Available For Sale Term Realized gains or losses recognized on sale or maturity of available-for-sale debt securities Debt Securities Available For Sale Realized Gain Loss Impairment charges or recoveries related to marketable securities Other Than Temporary Impairment Loss Debt Securities Available For Sale Lessee operating lease initial term of contract. Lessee operating lease monthly rent expense. Annual rent year over year increase percentage. Lessee operating lease rent abatement. Number of leased buildings. Tenant improvement allowance. Cash-collateralized letter of credit. Commitments and contingencies disclosure. Commitments and contingencies disclosure. Commitments And Contingencies Disclosure [Table] Commitments And Contingencies Disclosure [Table] Lease Contractual Term Lease Contractual Term [Axis] Lease Contractual Term Lease Contractual Term [Domain] Lease Agreement on June two thousand and twenty Lease Agreement on June 2020 Lease Agreement On June Two Thousand And Twenty [Member] Long-Lived Tangible Asset Property Plant And Equipment By Type [Axis] Long-Lived Tangible Asset Property Plant And Equipment Type [Domain] Building one. 1200 Page Mill Road in Palo Alto Building One [Member] Building two. 1250 Page Mill Road in Palo Alto Building Two [Member] Geographical Statement Geographical [Axis] Geographical Segment Geographical [Domain] California CALIFORNIA Lease agreement on April two thousand and twenty. Lease Agreement on April 2020 Lease Agreement On April Two Thousand And Twenty [Member] Office and laboratory space. Rottenstrasse 5 in Visp Office And Laboratory Space [Member] Switzerland SWITZERLAND Manufacturing agreement. Manufacturing Agreement Manufacturing Agreement [Member] Clinical and commercial supply. Clinical and Commercial Supply of Drug Substance Clinical And Commercial Supply [Member] Lease agreement on April and June two thousand and twenty Lease Agreement on April and June 2020 Lease Agreement On April And June Two Thousand And Twenty [Member] Counterparty Name Counterparty Name [Axis] Counterparty Name Repurchase Agreement Counterparty Name [Domain] Lonza. Lonza Lonza [Member] Finite-Lived Intangible Assets by Major Class Finite Lived Intangible Assets By Major Class [Axis] Finite-Lived Intangible Assets, Major Class Name Finite Lived Intangible Assets Major Class Name [Domain] Service Agreements Service Agreements [Member] Commitments And Contingencies Disclosure [Line Items] Commitments And Contingencies Disclosure [Line Items] Number of buildings leased Number Of Leased Buildings Lease area Area Of Land Initial lease term Lessee Operating Lease Initial Term Of Contract Monthly rent expense Lessee Operating Lease Monthly Rent Expense Annual rent year-over-year increase percentage Annual Rent Year Over Year Increase Percentage Total rent abatement Lessee Operating Lease Rent Abatement Tenant improvement allowance Tenant Improvement Allowance Cash-collateralized letter of credit Cash Collateralized Letter Of Credit Operating Lease Operating Lease Liabilities Payments Due [Abstract] 2020 Lessee Operating Lease Liability Payments Remainder Of Fiscal Year 2021 Lessee Operating Lease Liability Payments Due Next Twelve Months 2022 Lessee Operating Lease Liability Payments Due Year Two 2023 Lessee Operating Lease Liability Payments Due Year Three 2024 Lessee Operating Lease Liability Payments Due Year Four Thereafter Lessee Operating Lease Liability Payments Due After Year Four Total undiscounted lease payments Lessee Operating Lease Liability Payments Due Less: imputed interest Lessee Operating Lease Liability Undiscounted Excess Amount Total operating lease liabilities Operating Lease Liability Estimated capital contributions. Contractual obligation due in second year and after. Manufacturing agreement initial term. Manufacturing agreement term that can be extended. Estimated capital contribution Estimated Capital Contributions Annual suite fees payment for 2021 Contractual Obligation Due In Next Twelve Months Annual suite fees payment each year after 2021 Contractual Obligation Due In Second Year And After Manufacturing agreement initial term Manufacturing Agreement Initial Term Manufacturing agreement term that can be extended Manufacturing Agreement Term That Can Be Extended Lease liabilities Unrecorded unconditional purchase obligation cancellation fees. Cancelable and/ or non-cancelable purchase obligations, total Unrecorded Unconditional Purchase Obligation Balance Sheet Amount Unrecorded unconditional purchase obligation, expenses recognized Unrecorded Unconditional Purchase Obligation Purchases Unrecorded unconditional purchase obligation, cancellation fees Unrecorded Unconditional Purchase Obligation Cancellation Fees Related party transaction ownership percentage. Percentage of repurchase of royalties. Schedule Of Related Party Transactions By Related Party [Table] Schedule Of Related Party Transactions By Related Party [Table] Related Party Transaction [Line Items] Related Party Transaction [Line Items] Ownership percentage Related Party Transaction Ownership Percentage Percentage of repurchase of royalties Percentage Of Repurchase Of Royalties Funds payable upon enrollment of patients. Percentage of patients to be enrolled. Funds to be payable upon enrollment of patients Funds Payable Upon Enrollment Of Patients Percentage of patients to be enrolled Percentage Of Patients To Be Enrolled Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table] Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table] Plan Name Plan Name [Axis] Plan Name Plan Name [Domain] Two thousand eighteen equity incentive plan. 2018 Equity Incentive Plan Two Thousand Eighteen Equity Incentive Plan [Member] Award Type Award Type [Axis] Award Type Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain] Performance-based stock options. Performance-based Stock Options Performance Based Stock Options [Member] Performance-based restricted stock unit. Performance-based Restricted Stock Units Performance Based Restricted Stock Unit [Member] Performance based equity awards. Performance Based Equity Awards Performance Based Equity Awards [Member] Share Based Compensation Arrangement By Share Based Payment Award [Line Items] Share Based Compensation Arrangement By Share Based Payment Award [Line Items] Number of common stock available for issuance increased Share Based Compensation Arrangement By Share Based Payment Award Number Of Additional Shares Authorized Two thousand eighteen and two thousand fifteen equity incentive plan. 2018 Plan and 2015 Equity Incentive Plan Two Thousand Eighteen And Two Thousand Fifteen Equity Incentive Plan [Member] Number of Options Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Roll Forward Beginning balance Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number Granted Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross Exercised Forfeited or canceled Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures And Expirations In Period Ending balance Weighted Average Exercise Price Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price Rollforward Beginning balance Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price Granted Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price Exercised Share Based Compensation Arrangements By Share Based Payment Award Options Exercises In Period Weighted Average Exercise Price Forfeited or canceled Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures And Expirations In Period Weighted Average Exercise Price Ending balance Share-based compensation arrangement by share-based payment award, options, weighted average remaining contractual term. Weighted Average Remaining Contractual Term (in years) Share Based Compensation Arrangement By Share Based Payment Award Options Weighted Average Remaining Contractual Term [Abstract] Weighted Average Remaining Contractual Term (in years) Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term2 Share-based compensation arrangement by share-based payment award, options, aggregate intrinsic value. Aggregate Intrinsic Value Share Based Compensation Arrangement By Share Based Payment Award Options Aggregate Intrinsic Value [Abstract] Beginning balance Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value Ending balance Restricted Shares Restricted Stock [Member] Number of Restricted Shares Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Roll Forward Unvested, beginning balance Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Number Granted Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Vested Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Shares withheld related to net share settlement of RSUs Shares Paid For Tax Withholding For Share Based Compensation Canceled Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeited In Period Unvested, ending balance Shares withheld related to net share settlement of RSUs weighted average grant date fair value Weighted Average Grant Date Fair Value Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Grant Date Fair Value Roll Forward Unvested, beginning balance Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Grant Date Fair Value Granted Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Weighted Average Grant Date Fair Value Vested Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Weighted Average Grant Date Fair Value Shares withheld related to net share settlement of RSUs Shares Withheld Related To Net Share Settlement Of R S Us Weighted Average Grant Date Fair Value Canceled Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeitures Weighted Average Grant Date Fair Value Unvested, ending balance Share based compensation arrangement by share based payment award vesting period for achievement of specific milestone. Stock options, granted Stock units, granted Vesting period for achievement of specific milestone Share Based Compensation Arrangement By Share Based Payment Award Vesting Period For Achievement Of Specific Milestone Awards vested Stock-based compensation expense recognized Allocated Share Based Compensation Expense Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table] Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table] Income Statement Location Income Statement Location [Axis] Income Statement Location Income Statement Location [Domain] Research and Development Research And Development Expense [Member] General and Administrative General And Administrative Expense [Member] Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] Total stock-based compensation Unrecognized stock-based compensation expense Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Stock Options Unrecognized stock-based compensation weighted-average period expected for recognition Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1 Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table] Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table] Antidilutive Securities Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis] Antidilutive Securities, Name Antidilutive Securities Name [Domain] Outstanding Stock Options Employee Stock Option [Member] Unvested Restricted Shares Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] Anti-dilutive securities excluded from the computation of diluted net loss per common share Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount