Entity Address, City or Town Entity Address, City or Town Fair Value Disclosures [Abstract] Earnings Per Share [Abstract] Quoted Price in Active Markets (Level 1) Fair Value, Inputs, Level 1 [Member] Net cash provided by (used in) financing activities Net Cash Provided by (Used in) Financing Activities [Abstract] Net increase (decrease) in cash, cash equivalents and restricted cash Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Excluding Exchange Rate Effect Amendment Flag Amendment Flag Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized Issuance of common stock pursuant to employee stock purchase plans Subsequent Event Type Subsequent Event Type [Domain] Operating lease right-of-use asset Operating Lease, Right-of-Use Asset Long-Term Performance Incentive Plan Description Long-Term Performance Incentive Plan Description Plan description Debt Securities Available For Sale Unrealized Gains, Non Current Debt Securities Available For Sale Unrealized Gains, Non Current Unrealized Gains, Non Current Document Quarterly Report Document Quarterly Report Marketable Securities [Line Items] Marketable Securities [Line Items] Accrued legal fees Accrued Legal Fees Current Accrued legal fees current. Statement [Table] Statement [Table] Operating lease liability, net of current portion Operating Lease, Liability, Noncurrent Stock Issued During Period, Shares, Employee Stock Purchase Plans Issuance of common stock pursuant to employee stock purchase plans, shares Preferred Stock, Shares Outstanding, Ending Balance Preferred Stock, Shares Outstanding, Beginning Balance Preferred Stock, shares outstanding Preferred Stock, Shares Outstanding Common stock, shares reserved for issuance Common Stock, Capital Shares Reserved for Future Issuance Unvested, beginning balance Unvested, ending balance Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value Vested Manufacturing Agreement Expense Manufacturing Agreement Expense Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period, Total Forfeited or canceled Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period Employee-related Liabilities, Current, Total Accrued salaries and benefits Employee-related Liabilities, Current Outstanding Stock Options Share-Based Payment Arrangement, Option [Member] Total liabilities and stockholders' equity Total liabilities and stockholders’ equity Liabilities and Equity Plan Name Plan Name [Domain] Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code Income Statement [Abstract] Total current liabilities Liabilities, Current Liability related to sale of future royalties Liability Related To Sale Of Future Royalties Liability related to sale of future royalties. Stock based compensation expense related to ESPP Stock Issued During Period, Value, Employee Stock Purchase Plan Issuance of common stock pursuant to employee stock purchase plans Fair Value, Measurements, Recurring Fair Value, Recurring [Member] Interest Expense, Total Interest expense Interest Expense Commitments And Contingencies Disclosure [Line Items] Commitments And Contingencies Disclosure [Line Items] Commitments and contingencies disclosure. Schedule of Accrued and Other Current Liabilities Schedule Of Accrued And Other Current Liabilities Table [Text Block] Schedule of accrued and other current liabilities. Debt Securities, Available-for-Sale, Unrealized Loss Unrealized Losses, Current Preferred stock, shares authorized Preferred Stock, Shares Authorized Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table] Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table] Entity Small Business Entity Small Business Collaborative Arrangement and Arrangement Other than Collaborative Collaborative Arrangement and Arrangement Other than Collaborative [Axis] Sales Forecasting Sales Forecasting Sales Manufacturing agreement term that can be extended Manufacturing Agreement Term That Can Be Extended Manufacturing agreement term that can be extended. Total current assets Assets, Current Weighted Average Number of Shares Outstanding, Basic, Total Weighted Average Number of Shares Outstanding, Basic City Area Code City Area Code Balance Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value Share-Based Payment Arrangement [Abstract] Total liabilities Liabilities Document Period End Date Document Period End Date Unvested Restricted Shares Restricted Shares Restricted Stock [Member] Estimated Capital Contributions Estimated capital contributions. Revised estimated capital contribution Statistical Measurement Statistical Measurement [Axis] Summary of Marketable Securities Marketable Securities [Table Text Block] Consecutive Trading days Consecutive Trading Days Consecutive Trading Days Subsequent Event [Line Items] Subsequent Event [Line Items] Accounts Payable and Accrued Liabilities, Current [Abstract] Total assets Assets Earnings Per Share, Diluted, Total Earnings Per Share, Diluted Net loss per common share, diluted Summary of Anti-dilutive Securities Excluded from Computation of Diluted Net Loss per Common Share Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Entity Address, Postal Zip Code Entity Address, Postal Zip Code Document Fiscal Period Focus Document Fiscal Period Focus Preferred stock, $0.0001 par value, 10,000,000 shares authorized; 0 shares issued and outstanding at September 30, 2022 and December 31, 2021, respectively Preferred Stock, Value, Issued, Ending Balance Preferred Stock, Value, Issued, Beginning Balance Preferred Stock, Value, Issued, Total Preferred Stock, Value, Issued APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total Stock-based compensation expense APIC, Share-Based Payment Arrangement, Increase for Cost Recognition Interest income Investment Income, Interest Counterparty Name Counterparty Name [Domain] Operating Lease, Liability, Total Lease liabilities Operating Lease, Liability Net cash provided by financing activities Net Cash Provided by (Used in) Financing Activities Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract] Weighted Average Grant Date Fair Value Statement of Financial Position [Abstract] Entity File Number Entity File Number Statement of Cash Flows [Abstract] Statistical Measurement Statistical Measurement [Domain] Statement of Stockholders' Equity [Abstract] Common stock purchase price percentage Share-Based Compensation Arrangement by Share-Based Payment Award, Purchase Price of Common Stock, Percent Debt Securities, Available-for-Sale, Unrealized Gain Unrealized Gains, Current Subsequent Events [Abstract] Fair Value Measurements Fair Value Disclosures [Text Block] Other comprehensive income (loss) Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Debt Securities Available For Sale Unrealized Losses, Non Current Debt Securities Available For Sale Unrealized Losses, Non Current Unrealized Losses, Non Current Proceeds from issuance of common stock upon options exercise Proceeds from Stock Options Exercised Lease Agreement Lease Agreements [Member] Annual suite fees payment for 2021 Contractual Obligation, to be Paid, Year One Performance Periods Share Based Compensation Arrangement By Share Based Payment Award Options performance period Share Based Compensation Arrangement By Share Based Payment Award Options performance period Antidilutive Securities Antidilutive Securities [Axis] Preferred stock, par value Preferred Stock, Par or Stated Value Per Share Weighted Average Number of Shares Outstanding, Diluted, Total Weighted Average Number of Shares Outstanding, Diluted Deposits on property and equipment Deposits On Property And Equipment Deposits on property and equipment. Finite-Lived Intangible Assets, Major Class Name Finite-Lived Intangible Assets, Major Class Name [Domain] General and Administrative General and Administrative Expense [Member] Unrecognized compensation cost related to unvested share based awards Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount Current Fiscal Year End Date Current Fiscal Year End Date Depreciation, Total Depreciation Depreciation Financial Instruments [Domain] Cash, cash equivalents and restricted cash in consolidated balance sheets Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total Cash, cash equivalents and restricted cash, at beginning of period Cash, cash equivalents and restricted cash, at end of period Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations Cash, cash equivalents and restricted cash, at end of period Other Assets, Noncurrent, Total Other assets Other Assets, Noncurrent Entity Address, Address Line One Entity Address, Address Line One Finite-Lived Intangible Assets by Major Class Finite-Lived Intangible Assets by Major Class [Axis] Commitments And Contingencies Disclosure [Table] Commitments And Contingencies Disclosure [Table] Commitments and contingencies disclosure. Marketable Securities Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block] Restricted cash Restricted Cash, Noncurrent Operating lease liability Increase (Decrease) in Operating Lease Liability Forfeited or canceled Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period, Weighted Average Exercise Price Preferred Stock, Shares Issued, Total Preferred Stock, shares issued Preferred Stock, Shares Issued Balance Sheet Location [Domain] Accrued other liabilities Other Accrued Liabilities, Current Payments to Acquire Property, Plant, and Equipment, Total Purchase of property and equipment Payments to Acquire Property, Plant, and Equipment Accrued Research And Development Current Accrued research and development current. Accrued manufacturing and research & development costs Issuance of common stock upon vesting of restricted stock units Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures, Total Risk and Uncertainties Risk And Uncertainties Policy [Text Block] Risk and uncertainties. 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Entity Current Reporting Status Entity Current Reporting Status Asset Class Asset Class [Domain] Debt Securities, Available-for-sale, Current, Total Fair Value, current Debt Securities, Available-for-Sale, Current Other Assets [Member] Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested, Number of Shares Stock options, vested Total stockholders’ equity Beginning Balance Ending Balance Stockholders' Equity Attributable to Parent Term Of Offering Period Term of offering period. Term of offering period Debt Securities, Available-for-sale, Realized Gain (Loss), Total Realized gains or losses recognized on sale or maturity of available-for-sale debt securities Debt Securities, Available-for-Sale, Realized Gain (Loss) Accumulated Other Comprehensive Income (Loss) AOCI Attributable to Parent [Member] Purchase of property and equipment under accounts payable and accruals Noncash or Part Noncash Acquisition, Fixed Assets Acquired Marketable securities, effective maturities Debt Securities, Available-for-Sale, Term Asset Class Asset Class [Axis] Entity Tax Identification Number Entity Tax Identification Number Income Statement Location Income Statement Location [Axis] Canceled Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period Common stock, $0.0001 par value, 490,000,000 shares authorized at September 30, 2022 and December 31, 2021; 52,304,154 and 51,826,257 shares issued and outstanding at September 30, 2022 and December 31, 2021, respectively Common Stock, Value, Issued, Ending Balance Common Stock, Value, Issued, Beginning Balance Common Stock, Value, Issued, Total Common Stock, Value, Issued Retained Earnings (Accumulated Deficit), Ending Balance Retained Earnings (Accumulated Deficit), Beginning Balance Retained Earnings (Accumulated Deficit), Total Accumulated deficit Retained Earnings (Accumulated Deficit) Equity Components Equity Components [Axis] Performance-based Stock Options Performance Based Stock Options [Member] Performance-based stock options. Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent, Total Other Comprehensive Income (Loss), Available-for-Sale Securities Adjustment, Net of Tax, Portion Attributable to Parent Change in unrealized losses related to available-for-sale debt securities, net of tax Entity Emerging Growth Company Entity Emerging Growth Company Operating expenses Operating Expenses [Abstract] 2018 Employee Share Purchase Plan Two Thousand Eighteen Employee Share Purchase Plan [Member] Two thousand eighteen employee share purchase plan. Weighted Average Remaining Contractual Term and Aggregate Intrinsic Value Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Additional Disclosures [Abstract] Document Transition Report Document Transition Report Total Assets, Fair Value Disclosure Granted Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Accrued and Other Current Liabilities Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block] Issuance of common stock upon vesting of restricted stock units, shares Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures, Total Stock Price Sale of Stock, Price Per Share Commitments and Contingencies Commitments and Contingencies Disclosure [Text Block] Exercised Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] Accumulated other comprehensive income (loss) Accumulated Other Comprehensive Income (Loss), Net of Tax, Total Accumulated Other Comprehensive Income (Loss), Net of Tax Performance Based Equity Awards Performance Based Equity Awards [Member] Performance based equity awards. Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Debt Securities, Available-for-Sale, Amortized Cost, Noncurrent Amortized Cost, Non Current Net loss Net loss Net Income (Loss) Attributable to Parent Corporate Notes Corporate Note Securities [Member] Operating lease liability Operating Lease, Liability, Current Additional Paid-In Capital Additional Paid-in Capital [Member] Collaborative Arrangement and Arrangement Other than Collaborative Collaborative Arrangement and Arrangement Other than Collaborative [Domain] Manufacturing Agreement Manufacturing Agreement [Member] Manufacturing agreement. Entity Registrant Name Entity Registrant Name Cash and Cash Equivalents, at Carrying Value, Ending Balance Cash and Cash Equivalents, at Carrying Value, Beginning Balance Cash and Cash Equivalents, at Carrying Value, Total Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value Net Loss per Common Share Earnings Per Share [Text Block] Share-based Payment Arrangement, Noncash Expense, Total Stock-based compensation Share-Based Payment Arrangement, Noncash Expense Property, Plant and Equipment, Net, Ending Balance Property, Plant and Equipment, Net, Beginning Balance Property, Plant and Equipment, Net, Total Property and equipment, net Property, Plant and Equipment, Net Award Type Award Type [Domain] Statement [Line Items] Statement [Line Items] Performance expiration date Share Based Compensation Arrangement By Share Based Payment Award Options Performance Period Expiration Share based compensation arrangement by share based payment award options performance period expiration. Title of 12(b) Security Title of 12(b) Security Increase (Decrease) in Accounts Payable, Total Accounts payable Increase (Decrease) in Accounts Payable Common Stock Common Stock [Member] Cash flows from operating activities Net Cash Provided by (Used in) Operating Activities [Abstract] Equity Component Equity Component [Domain] Entity Address, State or Province Entity Address, State or Province Contractual Obligation Contractual Obligation, Total Annual suite fees payment Contractual obligation under funding agreement Operating lease right-of-use asset obtained in exchange for operating lease liability Operating lease right-of-use asset obtained in exchange for operating lease liability Operating lease right-of-use asset obtained in exchange for operating lease liability Operating lease right-of-use asset obtained in exchange for operating lease liability Document Type Document Type Entity Shell Company Entity Shell Company Total stock-based compensation Stock-based compensation expense recognized Share-Based Payment Arrangement, Expense Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table] Fair Value, Recurring and Nonrecurring [Table] 2018 Equity Incentive Plan Two Thousand Eighteen Equity Incentive Plan [Member] Two thousand eighteen equity incentive plan. Security Exchange Name Security Exchange Name Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Marketable Securities [Table] Marketable Securities [Table] Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] Net cash provided by (used in) operating activities Net Cash Provided by (Used in) Operating Activities Unrecognized compensation weighted-average period expected for recognition Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Weighted Average Remaining Contractual Term (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term Commitments and Contingencies Disclosure [Abstract] Debt Securities, Available-for-Sale, Amortized Cost, Current Amortized Cost, current Amortized Cost, current 2018 Plan and 2015 Equity Incentive Plan Two Thousand Eighteen And Two Thousand Fifteen Equity Incentive Plan [Member] Two thousand eighteen and two thousand fifteen equity incentive plan. Summary of stock options and performance-based stock options under 2021 LTPIP, 2018 Plan and 2015 Plan. Summary of Stock Options Activity under 2018 Plan and 2015 Equity Incentive Plan Share-Based Payment Arrangement, Option, Activity [Table Text Block] New Accounting Pronouncements, Policy [Policy Text Block] Recent accounting pronouncements Common Stock, Shares, Outstanding, Ending Balance Common Stock, Shares, Outstanding, Beginning Balance Common stock, shares outstanding Common Stock, Shares, Outstanding Amortization (accretion) of premium (discount) on marketable securities Accretion (Amortization) of Discounts and Premiums, Investments Significant Observable Inputs (Level 2) Fair Value, Inputs, Level 2 [Member] Debt Securities, Available-for-sale, Total Marketable securities Debt Securities, Available-for-Sale Cash flows from investing activities Net Cash Provided by (Used in) Investing Activities [Abstract] Commitments and contingencies (Note 6) Commitments and Contingencies Common Stock, Shares, Issued, Total Common stock, shares issued Common Stock, Shares, Issued U.S. Treasury Securities US Treasury Securities [Member] Minimum Minimum [Member] Marketable Securities Marketable Securities, Total Availability of Marketable Securities Total accrued and other current liabilities Accrued and other current liabilities Accrued Liabilities, Current Stockholders’ equity: Stockholders' Equity Attributable to Parent [Abstract] Performance Based Restricted Stock Units [Member] Performance Based Restricted Stock Units [Member] Performance Based Restricted Stock Units Counterparty Name Counterparty Name [Axis] Canceled Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Award Type Award Type [Axis] Subsequent Event Subsequent Event [Member] Other Nonoperating Income (Expense), Total Other income (expense), net Other Nonoperating Income (Expense) Research and Development Expense, Total Research and development Research and Development Expense Entity Central Index Key Entity Central Index Key Entity Central Index Key Accounting Policies [Abstract] Accrued and other current liabilities Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities Issuance of common stock upon exercise of common stock warrant Issuance Of Common Stock Upon Exercise Of Common Stock Warrants Issuance of common stock upon exercise of common stock warrants. Investments, Debt and Equity Securities [Abstract] Measurement Frequency Measurement Frequency [Axis] Stock-Based Compensation Share-Based Payment Arrangement [Text Block] Subsequent Event [Table] Subsequent Event [Table] General and Administrative Expense, Total General and administrative General and Administrative Expense Organization, Consolidation and Presentation of Financial Statements [Abstract] Clinical and Commercial Supply of Drug Substance Clinical And Commercial Supply [Member] Clinical and commercial supply. Beginning balance Ending balance Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price Research and Development Research and Development Expense [Member] Adjustments to reconcile net loss to net cash provided by (used in) operating activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Accumulated Deficit Retained Earnings [Member] Manufacturing agreement initial term Manufacturing Agreement Initial Term Manufacturing agreement initial term. Money Market Funds Money Market Funds [Member] Lonza Lonza [Member] Lonza. Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] Amortization of issuance costs Amortization Of Issuance Costs Amortization of issuance costs. Percentage of vested of award under performance based award Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage Entity Interactive Data Current Entity Interactive Data Current Supplemental disclosures of non-cash investing and financing information: Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Debt Securities, Available-for-sale, Allowance for Credit Loss, Ending Balance Debt Securities, Available-for-sale, Allowance for Credit Loss, Beginning Balance Debt Securities, Available-for-sale, Allowance for Credit Loss, Total Allowance for credit losses for available-for-sale debt securities Debt Securities, Available-for-Sale, Allowance for Credit Loss Vesting period for achievement of specific milestone Share Based Compensation Arrangement By Share Based Payment Award Vesting Period For Achievement Of Specific Milestone Share based compensation arrangement by share based payment award vesting period for achievement of specific milestone. Local Phone Number Local Phone Number Summary of Fair Value Hierarchy for Assets Measured at Fair Value on Recurring Basis Fair Value, Assets Measured on Recurring Basis [Table Text Block] Share Based Compensation Arrangement By Share Based Payment Award [Line Items] Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] Stock options, granted Granted Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross Other Liabilities, Noncurrent, Total Other liabilities Other Liabilities, Noncurrent Income Statement Location Income Statement Location [Domain] The Company The Company [Text Block] The entire disclosure for the company. Unvested, ending balance Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number Unvested, beginning balance Beginning balance, shares Ending balance, shares Shares, Outstanding Increase (Decrease) in Prepaid Expense and Other Assets, Total Prepaid expenses and other current assets Increase (Decrease) in Prepaid Expense and Other Assets Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table] Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table] Beginning balance Ending balance Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number Marketable Securities, Current, Total Marketable securities Marketable Securities, Current Document Fiscal Year Focus Document Fiscal Year Focus Accrued Leasehold Improvements Accrued Leasehold Improvements Earnings Per Share, Basic, Total Earnings Per Share, Basic Net loss per common share, basic Weighted Average Exercise Price Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] Assets Assets [Abstract] Reconciliation of cash, cash equivalents and restricted cash to consolidated balance sheets Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents [Abstract] 2021 LTPIP Two Thousand Twenty One Long-Term Performance Incentive Plan [Member] Two Thousand Twenty One Long-Term Performance Incentive Plan [Member] Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Summary of Significant Accounting Policies Summary of Significant Accounting Policies [Policy Text Block] Summary of Significant Accounting Policies [Policy Text Block] Financial Instrument [Axis] Long-Lived Tangible Asset Long-Lived Tangible Asset [Axis] Number of Options Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward] Liabilities and stockholders’ equity Liabilities and Equity [Abstract] Property and Equipment, Net Property, Plant and Equipment, Policy [Policy Text Block] Antidilutive Securities, Name Antidilutive Securities, Name [Domain] Current assets: Assets, Current [Abstract] Fair Value Hierarchy and NAV Fair Value Hierarchy and NAV [Domain] Measurement Frequency Measurement Frequency [Domain] Changes in assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] Investments and Cash, Total Investments and Cash Cash, cash equivalents and marketable securities Cover [Abstract] Other-than-temporary Impairment Loss, Debt Securities, Available-for-sale, Total Impairment charges or recoveries related to marketable securities Other-than-temporary Impairment Loss, Debt Securities, Available-for-Sale Awards vested Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period Vested Current liabilities: Liabilities, Current [Abstract] Number of purchase periods Number Of Purchase Periods Number of purchase periods. Maximum Maximum Maximum [Member] Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Excluding Option Exercised Proceeds from issuance of common stock pursuant to employee stock purchase plans Net cash provided by (used in) investing activities Net Cash Provided by (Used in) Investing Activities Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Exercised Issuance of common stock upon exercise of stock options, shares Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period Significant Unobservable Inputs (Level 3) Fair Value, Inputs, Level 3 [Member] Summary of Stock-based Compensation for Options and Restricted Shares Classified in Condensed Consolidated Statements of Operations and Comprehensive Loss Share-Based Payment Arrangement, Cost by Plan [Table Text Block] Use of Estimates Use of Estimates, Policy [Policy Text Block] Issuance of common stock upon exercise of stock options Stock Issued During Period, Value, Stock Options Exercised Accrued clinical trial and related costs Accrued Clinical Trial And Related Costs Current Accrued clinical trial and related costs current. Available For Sale Debt Securities , Non Current Available For Sale Debt Securities , Non Current Fair Value, Non Current Common stock, shares authorized Common Stock, Shares Authorized 2018 Plan, 2015 Equity Incentive Plan and 2021 LTPIP Two Thousand Eighteen And Two Thousand Fifteen Equity Incentive Plan And Two Thousand Twenty One Long Performance Incentive Plan [Member] Two Thousand Eighteen And Two Thousand Fifteen Equity Incentive Plan And Two Thousand Twenty One Long Performance Incentive Plan [Member] Trading Symbol Trading Symbol Issuance of common stock upon exercise of common stock warrant, shares Issuance Of Common Stock Upon Exercise Of Common Stock Warrants Shares Issuance of common stock upon exercise of common stock warrants, shares. 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Anti-dilutive securities excluded from the computation of diluted net loss per common share Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Cash equivalents Cash and Cash Equivalents, Fair Value Disclosure Annual suite fees payment Annual Suite Fees Payment Annual suite fees payment.